R306465 is a novel potent inhibitor of class I histone deacetylases with broad-spectrum antitumoral activity against solid and haematological malignancies

R306465 is a novel hydroxamate-based histone deacetylase (HDAC) inhibitor with broad-spectrum antitumour activity against solid and haematological malignancies in preclinical models. R306465 was found to be a potent inhibitor of HDAC1 and -8 (class I) in vitro. It rapidly induced histone 3 (H3) acet...

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Main Authors: Arts, J, Angibaud, P, Mariën, A, Floren, W, Janssens, B, King, P, van Dun, J, Janssen, L, Geerts, T, Tuman, R W, Johnson, D L, Andries, L, Jung, M, Janicot, M, van Emelen, K
פורמט: Artigo
שפה:Inglês
יצא לאור: Nature Publishing Group 2007
נושאים:
Translational Therapeutics
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC2360244/
https://ncbi.nlm.nih.gov/pubmed/18000499
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6604025
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