Schedule-dependent activity of 5-fluorouracil and irinotecan combination in the treatment of human colorectal cancer: in vitro evidence and a phase I dose-escalating clinical trial

Several schedules of 5-fluorouracil (FU) and irinotecan (IRI) have been shown to improve overall survival in advanced colorectal cancer (CRC). Preclinical evidence suggests that the sequential administration of IRI and FU produces synergistic activity, although their clinical use has not been fully...

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Detaylı Bibliyografya
Asıl Yazarlar: Barone, C, Landriscina, M, Quirino, M, Basso, M, Pozzo, C, Schinzari, G, Leonardo, G Di, D'Argento, E, Trigila, N, Cassano, A
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Nature Publishing Group 2007
Konular:
Clinical Study
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2360198/
https://ncbi.nlm.nih.gov/pubmed/17164761
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6603496
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