Schedule-dependent activity of 5-fluorouracil and irinotecan combination in the treatment of human colorectal cancer: in vitro evidence and a phase I dose-escalating clinical trial

Several schedules of 5-fluorouracil (FU) and irinotecan (IRI) have been shown to improve overall survival in advanced colorectal cancer (CRC). Preclinical evidence suggests that the sequential administration of IRI and FU produces synergistic activity, although their clinical use has not been fully...

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Detalhes bibliográficos
Main Authors: Barone, C, Landriscina, M, Quirino, M, Basso, M, Pozzo, C, Schinzari, G, Leonardo, G Di, D'Argento, E, Trigila, N, Cassano, A
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2007
Assuntos:
Clinical Study
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2360198/
https://ncbi.nlm.nih.gov/pubmed/17164761
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6603496
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