Telomere uncapping by the G-quadruplex ligand RHPS4 inhibits clonogenic tumour cell growth in vitro and in vivo consistent with a cancer stem cell targeting mechanism

The pentacyclic acridinium methosulfate salt RHPS4 induces the 3′single-stranded guanine-rich telomeric overhang to fold into a G-quadruplex structure. Stabilisation of the latter is incompatible with an attachment of telomerase to the telomere and thus G-quadruplex ligands can effectively inhibit b...

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Detalhes bibliográficos
Main Authors: Phatak, P, Cookson, J C, Dai, F, Smith, V, Gartenhaus, R B, Stevens, M F G, Burger, A M
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2007
Assuntos:
Translational Therapeutics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2360152/
https://ncbi.nlm.nih.gov/pubmed/17406367
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6603691
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