Anti-Cripto Mab inhibit tumour growth and overcome MDR in a human leukaemia MDR cell line by inhibition of Akt and activation of JNK/SAPK and bad death pathways

Doxorubicin (DOX) selection of CCRF-CEM leukaemia cell line resulted in multidrug resistance (MDR) CEM/A7R cell line, which overexpresses MDR, 1 coded P-glycoprotein (Pgp). Here, we report for the first time that oncoprotein Cripto, a founding member of epidermal growth factor-Cripto-FRL, 1-Criptic...

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Bibliographische Detailangaben
Hauptverfasser: Hu, X F, Li, J, Yang, E, Vandervalk, S, Xing, P X
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2007
Schlagworte:
Translational Therapeutics
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2360102/
https://ncbi.nlm.nih.gov/pubmed/17342096
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6603641
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