Changes in the status of p53 affect drug sensitivity to thymidylate synthase (TS) inhibitors by altering TS levels

Colorectal cancer (CRC) resistance to fluoropyrimidines and other inhibitors of thymidylate synthase (TS) is a serious clinical problem often associated with increased intracellular levels of TS. Since the tumour suppressor gene p53, which is mutated in 50% of CRC, regulates the expression of severa...

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Main Authors: Giovannetti, E, Backus, H H J, Wouters, D, Ferreira, C G, van Houten, V M M, Brakenhoff, R H, Poupon, M-F, Azzarello, A, Pinedo, H M, Peters, G J
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2007
Teme:
Translational Therapeutics
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2360080/
https://ncbi.nlm.nih.gov/pubmed/17339891
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6603639
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