De-regulation of the sonic hedgehog pathway in the InsGas mouse model of gastric carcinogenesis

This study investigated sonic hedgehog (Shh) signalling in gastric metaplasia in the insulin-gastrin (InsGas) hypergastrinaemic mouse +/− Helicobacter felis (H. felis) infection. Sonic hedgehog gene and protein expression was reduced in pre-metaplastic lesions from non-infected mice (90% gene reduct...

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Detalhes bibliográficos
Main Authors: El-Zaatari, M, Tobias, A, Grabowska, A M, Kumari, R, Scotting, P J, Kaye, P, Atherton, J, Clarke, P A, Powe, D G, Watson, S A
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2007
Assuntos:
Translational Therapeutics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2359963/
https://ncbi.nlm.nih.gov/pubmed/17505514
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6603782
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