The Metalloprotease Meprinβ Processes E-Cadherin and Weakens Intercellular Adhesion

BACKGROUND: Meprin (EC 3.4.24.18), an astacin-like metalloprotease, is expressed in the epithelium of the intestine and kidney tubules and has been related to cancer, but the mechanistic links are unknown. METHODOLOGY/PRINCIPAL FINDINGS: We used MDCK and Caco-2 cells stably transfected with meprinα...

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Detalhes bibliográficos
Main Authors: Huguenin, Maya, Müller, Eliane J., Trachsel-Rösmann, Sandra, Oneda, Beatrice, Ambort, Daniel, Sterchi, Erwin E., Lottaz, Daniel
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2008
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2359857/
https://ncbi.nlm.nih.gov/pubmed/18478055
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0002153
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