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Updates on p53: modulation of p53 degradation as a therapeutic approach

The p53 pathway is aberrant in most human tumours with over 50% expressing mutant p53 proteins. The pathway is critically controlled by protein degradation. Here, we discuss the latest developments in the search for small molecules that can modulate p53 pathway protein stability and restore p53 acti...

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Detalhes bibliográficos
Main Authors: Dey, A, Verma, C S, Lane, D P
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2359710/
https://ncbi.nlm.nih.gov/pubmed/18182973
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6604098
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