On roads not taken in the evolution of protein catalysts: Antibody steroid isomerases that use an enamine mechanism

Reactive immunization has emerged as a new tool for the study of biological catalysis. A powerful application resulted in catalytic antibodies that use an enamine mechanism akin to that used by the class I aldolases. With regard to the evolution of enzyme mechanisms, we investigated the utility of a...

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Bibliographic Details
Main Authors: Lin, Chao-Hsiung, Hoffman, Timothy Z., Wirsching, Peter, Barbas, Carlos F., Janda, Kim D., Lerner, Richard A.
Format: Artigo
Language:Inglês
Published: The National Academy of Sciences of the USA 1997
Subjects:
Physical Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC23568/
https://ncbi.nlm.nih.gov/pubmed/9342312
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