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On roads not taken in the evolution of protein catalysts: Antibody steroid isomerases that use an enamine mechanism

Reactive immunization has emerged as a new tool for the study of biological catalysis. A powerful application resulted in catalytic antibodies that use an enamine mechanism akin to that used by the class I aldolases. With regard to the evolution of enzyme mechanisms, we investigated the utility of a...

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Sonraí bibleagrafaíochta
Foilsithe in:Proc Natl Acad Sci U S A
Príomhchruthaitheoirí: Lin, Chao-Hsiung, Hoffman, Timothy Z., Wirsching, Peter, Barbas, Carlos F., Janda, Kim D., Lerner, Richard A.
Formáid: Artigo
Teanga:Inglês
Foilsithe / Cruthaithe: National Academy of Sciences 1997
Ábhair:
Rochtain ar líne:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC23568/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9342312/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.94.22.11773
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