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A single in vivo administration of bombesin antagonist RC-3095 reduces the levels and mRNA expression of epidermal growth factor receptors in MXT mouse mammary cancers

Epidermal growth factor (EGF) and its receptors (EGFR) play important roles in tumorigenesis. In various experimental cancers, treatment with antagonists of bombesin/gastrin-releasing peptide (BN/GRP) produces a reduction in EGFRs, concomitant to inhibition of tumor growth. To investigate the mechan...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Szepeshazi, Karoly, Schally, Andrew V., Halmos, Gabor, Lamharzi, Najib, Groot, Kate, Horvath, Judit E.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1997
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC23529/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9380734/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.94.20.10913
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