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Synthesis of hindered biphenyls by sequential non-transition metal-catalyzed reaction/palladium-catalyzed cross-couplings

The sequential reaction of 1,2-dihalobenzenes with aryl lithiums followed by palladium-catalyzed cross-coupling reactions with Grignard reagents and arylboronic acids is described. This sequential reaction provides a convenient and expeditious access to tri-ortho substituted biaryl derivatives.

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Detalhes bibliográficos
Main Authors: He, Ping, Dong, Cheng-Guo, Hu, Qiao-Sheng
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2350223/
https://ncbi.nlm.nih.gov/pubmed/19295906
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tetlet.2008.01.101
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