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The Intrinsic Immunoglobulin G Endopeptidase Activity of Streptococcal Mac-2 Proteins Implies a Unique Role for the Enzymatically Impaired Mac-2 Protein of M28 Serotype Strains

IdeS, a secreted cysteine protease of the important human pathogen Streptococcus pyogenes, interferes with phagocytic killing by specifically cleaving the heavy chain of immunoglobulin G (IgG). Two allelic variants of the enzyme have been described, the IgG-specific endopeptidase, IdeS (or Mac-1) an...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Söderberg, Jenny Johansson, Engström, Patrik, von Pawel-Rammingen, Ulrich
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Microbiology (ASM) 2008
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2346711/
https://ncbi.nlm.nih.gov/pubmed/18332209
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.01422-07
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