2-(4′-CHLOROPHENYL)-1,4-BENZOQUINONE INCREASES THE FREQUENCY OF MICRONUCLEI AND SHORTENS TELOMERES

The toxicity of polychlorinated biphenyls (PCBs) has been attributed widely to receptor-mediated effects, buttressed by the popularity of the Toxic Equivalency Factor. We propose that a crucial toxic mechanism of lower-chlorinated PCBs is their enzymatic biotransformation to electrophiles, including...

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Hlavní autoři: Jacobus, J.A., Flor, S., Klingelhutz, A., Robertson, L.W., Ludewig, G.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2008
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2346440/
https://ncbi.nlm.nih.gov/pubmed/18438462
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.etap.2007.10.022
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