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Evolution of the folding ability of proteins through functional selection

An evolutionary process is simulated with a simple spin-glass-like model of proteins to examine the origin of folding ability. At each generation, sequences are randomly mutated and subjected to a simulation of the folding process based on the model. According to the frequency of local configuration...

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Detalles Bibliográficos
Main Authors: Saito, Seiji, Sasai, Masaki, Yomo, Tetsuya
Formato: Artigo
Idioma:Inglês
Publicado: The National Academy of Sciences of the USA 1997
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC23457/
https://ncbi.nlm.nih.gov/pubmed/9326608
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