Probing the Stability of Native and Activated Forms of α(2)-macroglobulin

α(2)-macroglobulin (α(2)M) is a 718 kDa homotetrameric proteinase inhibitor which undergoes a large conformational change upon activation. This conformational change can occur either by proteolytic attack on an ~40 amino acid stretch, the bait region, which results in the rupture of the four thioest...

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Bibliographic Details
Main Authors:	Kaczowka, Steven J., Madding, Lara S., Epting, Kevin L., Kelly, Robert M., Cianciolo, George J., Pizzo, Salvatore V.
Format:	Artigo
Language:	Inglês
Published:	2007
Subjects:	Article
Online Access:	https://ncbi.nlm.nih.gov/pmc/articles/PMC2344126/ https://ncbi.nlm.nih.gov/pubmed/17996290 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ijbiomac.2007.09.019
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Probing the Stability of Native and Activated Forms of α(2)-macroglobulin

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