Dual targeting of the proteasome regulates survival and homing in Waldenström macroglobulinemia

Waldenström macroglobulinemia (WM) is an incurable low-grade B-cell lymphoma characterized by high protein turnover. We dissected the biologic role of the proteasome in WM using 2 proteasome inhibitors, NPI-0052 and bortezomib. We found that NPI-0052 inhibited proliferation and induced apoptosis in...

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Hauptverfasser: Roccaro, Aldo M., Leleu, Xavier, Sacco, Antonio, Jia, Xiaoying, Melhem, Molly, Moreau, Anne-Sophie, Ngo, Hai T., Runnels, Judith, Azab, Abdelkareem, Azab, Feda, Burwick, Nicholas, Farag, Mena, Treon, Steven P., Palladino, Michael A., Hideshima, Teru, Chauhan, Dharminder, Anderson, Kenneth C., Ghobrial, Irene M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society of Hematology 2008
Schlagworte:
Neoplasia
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2343604/
https://ncbi.nlm.nih.gov/pubmed/18316628
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2007-11-120972
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