RB and hbrm cooperate to repress the activation functions of E2F1

Forced expression of the retinoblastoma (RB) gene product inhibits the proliferation of cells in culture. A major target of the RB protein is the S-phase-inducing transcription factor E2F1. RB binds directly to the activation domain of E2F1 and silences it, thereby preventing cells from entering S p...

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Pubblicato in:	Proc Natl Acad Sci U S A
Autori principali:	Trouche, Didier, Le Chalony, Catherine, Muchardt, Christian, Yaniv, Moshe, Kouzarides, Tony
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	National Academy of Sciences 1997
Soggetti:	Biological Sciences
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC23436/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9326598/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.94.21.11268
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