RB and hbrm cooperate to repress the activation functions of E2F1

Forced expression of the retinoblastoma (RB) gene product inhibits the proliferation of cells in culture. A major target of the RB protein is the S-phase-inducing transcription factor E2F1. RB binds directly to the activation domain of E2F1 and silences it, thereby preventing cells from entering S p...

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Bibliographic Details
Main Authors: Trouche, Didier, Le Chalony, Catherine, Muchardt, Christian, Yaniv, Moshe, Kouzarides, Tony
Format: Artigo
Language:Inglês
Published: The National Academy of Sciences of the USA 1997
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC23436/
https://ncbi.nlm.nih.gov/pubmed/9326598
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