Mutant MiRP1 subunits modulate HERG K(+) channel gating: a mechanism for pro-arrhythmia in long QT syndrome type 6

Mutations in KCNE2, which encodes the minK-related protein 1 (MiRP1), are associated with an increased risk of arrhythmias; however, the underlying mechanisms are unknown. MiRP1 is thought to associate with many K(+) channel α-subunits, including HERG K(+) channels, which have a major role in suppre...

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Bibliografske podrobnosti
Main Authors: Lu, Yu, Mahaut-Smith, Martyn P, Huang, Christopher L-H, Vandenberg, Jamie I
Format: Artigo
Jezik:Inglês
Izdano: Blackwell Science Inc 2003
Teme:
Original Articles
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2343156/
https://ncbi.nlm.nih.gov/pubmed/12923204
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2003.046045
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