Acidosis decreases low Ca(2+) -induced neuronal excitation by inhibiting the activity of calcium-sensing cation channels in cultured mouse hippocampal neurons

The effects of extracellular pH (pH(o)) on calcium-sensing non-selective cation (csNSC) channels in cultured mouse hippocampal neurons were investigated using whole-cell voltage-clamp and current-clamp recordings. Decreasing extracellular Ca(2+) concentrations ([Ca(2+)](o)) activated slow and sustai...

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Detalhes bibliográficos
Main Authors: Chu, Xiang-Ping, Zhu, Xiao-Man, Wei, Wen-Li, Li, Guo-Hua, Simon, Roger P, MacDonald, John F, Xiong, Zhi-Gang
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2003
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2343034/
https://ncbi.nlm.nih.gov/pubmed/12777448
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2003.043091
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