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Thrombin inhibits NMDA-mediated nociceptive activity in the mouse: possible mediation by endothelin
The CNS expresses many components of an extracellular protease signalling system, including the protease-activated receptor-1 (PAR-1) whose tethered ligand is generated by thrombin. Activation of PAR-1 potentiates NMDA receptor activity in hippocampal neurons. Because NMDA activity mediates hyperalg...
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| Главные авторы: | , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Blackwell Science Inc
2003
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2342990/ https://ncbi.nlm.nih.gov/pubmed/12717003 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2002.036384 |
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