Thrombin inhibits NMDA-mediated nociceptive activity in the mouse: possible mediation by endothelin

The CNS expresses many components of an extracellular protease signalling system, including the protease-activated receptor-1 (PAR-1) whose tethered ligand is generated by thrombin. Activation of PAR-1 potentiates NMDA receptor activity in hippocampal neurons. Because NMDA activity mediates hyperalg...

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Bibliografske podrobnosti
Main Authors: Fang, Ming, Kovács, Katalin J, Fisher, Lauralei L, Larson, Alice A
Format: Artigo
Jezik:Inglês
Izdano: Blackwell Science Inc 2003
Teme:
Original Articles
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2342990/
https://ncbi.nlm.nih.gov/pubmed/12717003
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2002.036384
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