GTP-induced tetrodotoxin-resistant Na(+) current regulates excitability in mouse and rat small diameter sensory neurones

Peripheral pain thresholds are regulated by the actions of inflammatory mediators. Some act through G-protein-coupled receptors on voltage-gated sodium channels. We have found that a low-threshold, persistent tetrodotoxin-resistant Na(+) current, attributed to Na(V)1.9, is upregulated by GTP and its...

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Detalhes bibliográficos
Main Authors: Baker, Mark D, Chandra, Sonia Y, Ding, Yanning, Waxman, Stephen G, Wood, John N
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2003
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2342858/
https://ncbi.nlm.nih.gov/pubmed/12651922
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2003.039131
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