The chemokine CXCL1/growth related oncogene increases sodium currents and neuronal excitability in small diameter sensory neurons

BACKGROUND: Altered Na(+ )channel expression, enhanced excitability, and spontaneous activity occur in nerve-injury and inflammatory models of pathological pain, through poorly understood mechanisms. The cytokine GRO/KC (growth related oncogene; CXCL1) shows strong, rapid upregulation in dorsal root...

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Detalhes bibliográficos
Main Authors: Wang, Jun-Gang, Strong, Judith A, Xie, Wenrui, Yang, Rui-Hua, Coyle, Dennis E, Wick, Dayna M, Dorsey, Ericka D, Zhang, Jun-Ming
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2008
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2562993/
https://ncbi.nlm.nih.gov/pubmed/18816377
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1744-8069-4-38
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