Kv1.4 channel block by quinidine: evidence for a drug-induced allosteric effect

We studied quinidine block of Kv1.4ΔN, a K(+) channel lacking N-type inactivation, expressed in Xenopus ooctyes. Initially, quinidine intracellularly blocked the open channel so rapidly it overlapped with activation. This rapid open channel block was reduced (non-additively) by interventions that sl...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Wang, Shimin, Morales, Michael J, Qu, Yu-Jie, Bett, Glenna C L, Strauss, Harold C, Rasmusson, Randall L
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Blackwell Science Inc 2003
Pynciau:
Original Articles
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2342510/
https://ncbi.nlm.nih.gov/pubmed/12527726
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2002.029512
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