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Kv1.4 channel block by quinidine: evidence for a drug-induced allosteric effect
We studied quinidine block of Kv1.4ΔN, a K(+) channel lacking N-type inactivation, expressed in Xenopus ooctyes. Initially, quinidine intracellularly blocked the open channel so rapidly it overlapped with activation. This rapid open channel block was reduced (non-additively) by interventions that sl...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Blackwell Science Inc
2003
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2342510/ https://ncbi.nlm.nih.gov/pubmed/12527726 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2002.029512 |
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