A yeast sterol auxotroph (erg25) is rescued by addition of azole antifungals and reduced levels of heme
Genetic disruption of the Saccharomyces cerevisiae C-4 sterol methyl oxidase ERG25 gene leads to sterol auxotrophy. We have characterized a suppression system that requires two mutations to restore viability to this disrupted strain. One suppressor mutation is erg11, which is blocked in 14α-demethyl...
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| Udgivet i: | Proc Natl Acad Sci U S A |
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| Principais autores: | , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
National Academy of Sciences
1997
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC23406/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9326581/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.94.21.11173 |
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