Antibodies to ribosomal P proteins of Trypanosoma cruzi in Chagas disease possess functional autoreactivity with heart tissue and differ from anti-P autoantibodies in lupus

Anti-P antibodies present in sera from patients with chronic Chagas heart disease (cChHD) recognize peptide R13, EEEDDDMGFGLFD, which encompasses the C-terminal region of the Trypanosoma cruzi ribosomal P1 and P2 proteins. This peptide shares homology with the C-terminal region (peptide H13 EESDDDMG...

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Autors principals: Kaplan, Dan, Ferrari, Ines, Bergami, Pablo Lopez, Mahler, Evelina, Levitus, Gabriela, Chiale, Pablo, Hoebeke, Johan, Van Regenmortel, Marc H. V., Levin, Mariano J.
Format: Artigo
Idioma:Inglês
Publicat: The National Academy of Sciences of the USA 1997
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC23357/
https://ncbi.nlm.nih.gov/pubmed/9294205
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