Covalent Inactivation of Factor VIII Antibodies from Hemophilia A Patients by an Electrophilic FVIII Analog

The antigen-binding sites of antibodies (Abs) can express enzyme-like nucleophiles that react covalently with electrophilic compounds. We examined the irreversible and specific inactivation of antibodies (Abs) to Factor VIII (FVIII) responsible for failure of FVIII replacement therapy in hemophilia...

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Bibliografiska uppgifter
Huvudupphovsmän: Planque, Stephanie, Escobar, Miguel A., Smith, Keri C., Taguchi, Hiroaki, Nishiyama, Yasuhiro, Donnachie, Elizabeth, Pratt, Kathleen P., Paul, Sudhir
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Biochemistry and Molecular Biology 2008
Ämnen:
Protein Synthesis, Post-Translational Modification, and Degradation
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2335366/
https://ncbi.nlm.nih.gov/pubmed/18337255
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M800589200
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