Fbxw7 acts as a critical fail-safe against premature loss of hematopoietic stem cells and development of T-ALL

Common molecular machineries between hematopoietic stem cell (HSC) maintenance and leukemia prevention have been highlighted. The tumor suppressor Fbxw7 (F-box and WD-40 domain protein 7), a subunit of an SCF-type ubiquitin ligase complex, induces the degradation of positive regulators of the cell c...

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Библиографические подробности
Главные авторы: Matsuoka, Sahoko, Oike, Yuichi, Onoyama, Ichiro, Iwama, Atsushi, Arai, Fumio, Takubo, Keiyo, Mashimo, Yoichi, Oguro, Hideyuki, Nitta, Eriko, Ito, Keisuke, Miyamoto, Kana, Yoshiwara, Hiroki, Hosokawa, Kentaro, Nakamura, Yuka, Gomei, Yumiko, Iwasaki, Hiroko, Hayashi, Yasuhide, Matsuzaki, Yumi, Nakayama, Keiko, Ikeda, Yasuo, Hata, Akira, Chiba, Shigeru, Nakayama, Keiichi I., Suda, Toshio
Формат: Artigo
Язык:Inglês
Опубликовано: Cold Spring Harbor Laboratory Press 2008
Предметы:
Research Communication
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2335330/
https://ncbi.nlm.nih.gov/pubmed/18367647
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1621808
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