Angiotensin II Up-Regulates Angiotensin I-Converting Enzyme (ACE), but Down-Regulates ACE2 via the AT1-ERK/p38 MAP Kinase Pathway

The recent discovery of the angiotensin II (Ang II)-breakdown enzyme, angiotensin I converting enzyme (ACE) 2, suggests the importance of Ang II degradation in hypertension. The present study explored the signaling mechanism by which ACE2 is regulated under hypertensive conditions. Real-time PCR and...

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Detalhes bibliográficos
Main Authors: Koka, Vijay, Huang, Xiao Ru, Chung, Arthur C.K., Wang, Wansheng, Truong, Luan D., Lan, Hui Yao
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2008
Assuntos:
Regular Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2329828/
https://ncbi.nlm.nih.gov/pubmed/18403595
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2008.070762
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