Tumor necrosis factor α plays a central role in immune-mediated clearance of adenoviral vectors

Adenovirus (Ad) gene transfer vectors are rapidly cleared from infected hepatocytes in mice. To determine which effector mechanisms are responsible for elimination of the Ad vectors, we infected mice that were genetically compromised in immune effector pathways [perforin, Fas, or tumor necrosis fact...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Elkon, Keith B., Liu, Chau-Ching, Gall, Jason G., Trevejo, Jose, Marino, Michael W., Abrahamsen, Karil A., Song, Xin, Zhou, Jun-Liang, Old, Lloyd J., Crystal, Ronald G., Falck-Pedersen, Erik
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1997
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC23274/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9275208/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.94.18.9814
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