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Tumor necrosis factor α plays a central role in immune-mediated clearance of adenoviral vectors

Adenovirus (Ad) gene transfer vectors are rapidly cleared from infected hepatocytes in mice. To determine which effector mechanisms are responsible for elimination of the Ad vectors, we infected mice that were genetically compromised in immune effector pathways [perforin, Fas, or tumor necrosis fact...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Elkon, Keith B., Liu, Chau-Ching, Gall, Jason G., Trevejo, Jose, Marino, Michael W., Abrahamsen, Karil A., Song, Xin, Zhou, Jun-Liang, Old, Lloyd J., Crystal, Ronald G., Falck-Pedersen, Erik
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1997
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC23274/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9275208/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.94.18.9814
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