Small-molecule RETRA suppresses mutant p53-bearing cancer cells through a p73-dependent salvage pathway

Identification of unique features of cancer cells is important for defining specific and efficient therapeutic targets. Mutant p53 is present in nearly half of all cancer cases, forming a promising target for pharmacological reactivation. In addition to being defective for the tumor-suppressor funct...

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Autori principali: Kravchenko, J. E., Ilyinskaya, G. V., Komarov, P. G., Agapova, L. S., Kochetkov, D. V., Strom, E., Frolova, E. I., Kovriga, I., Gudkov, A. V., Feinstein, E., Chumakov, P. M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2008
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2327210/
https://ncbi.nlm.nih.gov/pubmed/18424558
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0802091105
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