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Generation of αβ T-cell receptor(+) CD4(−) CD8(+) cells in major histocompatibility complex class I-deficient mice upon activation of the aryl hydrocarbon receptor by 2,3,7,8-tetrachlorodibenzo-p-dioxin
Gene-targeted mice lacking the β(2) microglobulin gene (β(2)m(−/−) mice), and hence functional major histocompatibility complex (MHC) class I molecules, do not develop CD4(–) CD8(+) cells. We show here that both in vitro and in vivo treatment with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), a trans-...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Blackwell Science Inc
2000
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2326997/ https://ncbi.nlm.nih.gov/pubmed/10886394 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.1365-2567.2000.00022.x |
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