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Rheumatoid factor isotype switch and somatic mutation variants within rheumatoid arthritis synovium
The presence of clonally-related B-lymphocyte aggregates within synovial lining tisue of rheumatoid arthritis (RA) patients suggests a germinal centre-like reaction, which may hold implications for disease pathogenesis and the causes of chronic inflammation. We studied 250 rheumatoid factor (RF) hea...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Blackwell Science Inc
1999
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2326907/ https://ncbi.nlm.nih.gov/pubmed/10469243 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.1365-2567.1999.00841.x |
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