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Regional analysis of p53 mutations in rheumatoid arthritis synovium

The p53 tumor suppressor protein plays a central role in cell cycle regulation, DNA repair, and apoptosis. Recent studies indicate that DNA damage and somatic mutations in the p53 gene can occur because of genotoxic stress in many tissues, including the skin, colon, and synovium. Although somatic mu...

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Main Authors: Yamanishi, Yuji, Boyle, David L., Rosengren, Sanna, Green, Douglas R., Zvaifler, Nathan J., Firestein, Gary S.
Formato: Artigo
Idioma:Inglês
Publicado: The National Academy of Sciences 2002
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC126618/
https://ncbi.nlm.nih.gov/pubmed/12119414
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.152333199
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