Interleukin-12 can directly induce T-helper 1 responses in interferon-γ (IFN-γ) receptor-deficient mice, but requires IFN-γ signalling to downregulate T-helper 2 responses

An in vivo model of pulmonary granuloma formation around embolized schistosome eggs was investigated as an environment in which to analyse a role for interleukin-12 (IL-12) in the differentiation of T-helper 1 (Th1) and Th2 subsets. Specifically, mice deficient for the interferon-γ receptor (IFN-γR(...

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Bibliographic Details
Main Authors:	Mountford, A P, Coulson, P S, Cheever, A W, Sher, A, Wilson, R A, Wynn, T A
Format:	Artigo
Language:	Inglês
Published:	Blackwell Science Inc 1999
Subjects:	Original Articles
Online Access:	https://ncbi.nlm.nih.gov/pmc/articles/PMC2326872/ https://ncbi.nlm.nih.gov/pubmed/10457211 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.1365-2567.1999.00832.x
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Interleukin-12 can directly induce T-helper 1 responses in interferon-γ (IFN-γ) receptor-deficient mice, but requires IFN-γ signalling to downregulate T-helper 2 responses

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