Mecillinam resistance in Escherichia coli is conferred by loss of a second activity of the AroK protein.

Mecillinam, a beta-lactam antibiotic specific to penicillin-binding protein 2 (PBP 2) in Escherichia coli, blocks cell wall elongation and, indirectly, cell division, but its lethality can be overcome by increased levels of ppGpp, the nucleotide effector of the stringent response. We have subjected...

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Detalles Bibliográficos

Publicado en:	J Bacteriol
Autores principales:	Vinella, D, Gagny, B, Joseleau-Petit, D, D'Ari, R, Cashel, M
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	American Society for Microbiology (ASM) 1996
Materias:	Research Article
Acceso en línea:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC232642/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8682786/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jb.178.13.3818-3828.1996
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