Mecillinam resistance in Escherichia coli is conferred by loss of a second activity of the AroK protein.

Mecillinam, a beta-lactam antibiotic specific to penicillin-binding protein 2 (PBP 2) in Escherichia coli, blocks cell wall elongation and, indirectly, cell division, but its lethality can be overcome by increased levels of ppGpp, the nucleotide effector of the stringent response. We have subjected...

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Bibliografiske detaljer

Udgivet i:	J Bacteriol
Principais autores:	Vinella, D, Gagny, B, Joseleau-Petit, D, D'Ari, R, Cashel, M
Format:	Artigo
Sprog:	Inglês
Udgivet:	American Society for Microbiology (ASM) 1996
Fag:	Research Article
Online adgang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC232642/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8682786/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jb.178.13.3818-3828.1996
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