Active efflux of fluoroquinolones in Mycobacterium smegmatis mediated by LfrA, a multidrug efflux pump.

The lfrA gene cloned from chromosomal DNA of quinolone-resistant Mycobacterium smegmatis mc2-552 conferred low-level resistance to fluoroquinolones when present on multicopy plasmids. Sequence analysis suggested that lfrA encodes a membrane efflux pump of the major facilitator family (H. E. Takiff,...

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Pubblicato in:	J Bacteriol
Autori principali:	Liu, J, Takiff, H E, Nikaido, H
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 1996
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC232638/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8682782/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jb.178.13.3791-3795.1996
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