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Adenovirus-mediated overexpression of IRS-1 interacting domains abolishes insulin-stimulated mitogenesis without affecting glucose transport in 3T3-L1 adipocytes.

Activated insulin receptor (IR) interacts with its substrates, IRS-1, IRS-2, and Shc via the NPXY motif centered at Y960. This interaction is important for IRS-1 phosphorylation. Studies using the yeast two-hybrid system and sequence identity analysis between IRS-1 and IRS-2 have identified two puta...

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Udgivet i:Mol Cell Biol
Principais autores: Sharma, P M, Egawa, K, Gustafson, T A, Martin, J L, Olefsky, J M
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 1997
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC232594/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9372969/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.17.12.7386
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