Tumor necrosis factor alpha and interleukin-1beta regulate the murine manganese superoxide dismutase gene through a complex intronic enhancer involving C/EBP-beta and NF-kappaB.

Manganese superoxide dismutase (MnSOD), a tumor necrosis factor (TNF)-inducible reactive oxygen-scavenging enzyme, protects cells from TNF-mediated apoptosis. To understand how MnSOD is regulated, transient transfections of promoter-reporter gene constructions, in vitro DNA binding assays, and in vi...

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Veröffentlicht in:	Mol Cell Biol
Hauptverfasser:	Jones, P L, Ping, D, Boss, J M
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Taylor & Francis 1997
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC232554/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9372929/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.17.12.6970
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