Initiation of DNA interstrand cross-link repair in humans: the nucleotide excision repair system makes dual incisions 5' to the cross-linked base and removes a 22- to 28-nucleotide-long damage-free strand.

Most DNA repair mechanisms rely on the redundant information inherent to the duplex to remove damaged nucleotides and replace them with normal ones, using the complementary strand as a template. Interstrand cross-links pose a unique challenge to the DNA repair machinery because both strands are dama...

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Sonraí Bibleagrafaíochta
Main Authors: Bessho, T, Mu, D, Sancar, A
Formáid: Artigo
Teanga:Inglês
Foilsithe: 1997
Ábhair:
Research Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC232538/
https://ncbi.nlm.nih.gov/pubmed/9372913
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