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p53-independent apoptosis induced by paclitaxel through an indirect mechanism

The efficacy of chemotherapeutic agents may be determined by a number of different factors, including the genotype of the tumor cell. The p53 tumor suppressor gene frequently is mutated in human tumors, and this may contribute to chemotherapeutic resistance. We tested the requirement for wild-type p...

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Autors principals: Lanni, Jennifer S., Lowe, Scott W., Licitra, Edward J., Liu, Jun O., Jacks, Tyler
Format: Artigo
Idioma:Inglês
Publicat: The National Academy of Sciences of the USA 1997
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC23249/
https://ncbi.nlm.nih.gov/pubmed/9275183
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