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Reciprocal interference between the sequence-specific core and nonspecific C-terminal DNA binding domains of p53: implications for regulation.

The tumor suppressor p53 has two DNA binding domains: a central sequence-specific domain and a C-terminal sequence-independent domain. Here, we show that binding of large but not small DNAs by the C terminus of p53 negatively regulates sequence-specific DNA binding by the central domain. Four previo...

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Udgivet i:Mol Cell Biol
Principais autores: Anderson, M E, Woelker, B, Reed, M, Wang, P, Tegtmeyer, P
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 1997
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC232476/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9343386/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.17.11.6255
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