Dual mechanisms for the inhibition of E2F binding to RB by cyclin-dependent kinase-mediated RB phosphorylation.
The growth suppression function of RB is dependent on its protein binding activity. RB contains at least three distinct protein binding functions: (i) the A/B pocket, which binds proteins with the LXCXE motif; (ii) the C pocket, which binds the c-Abl tyrosine kinase; and (iii) the large A/B pocket,...
Sparad:
| I publikationen: | Mol Cell Biol |
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| Huvudupphov: | , |
| Materialtyp: | Artigo |
| Språk: | Inglês |
| Utgiven: |
Taylor & Francis
1997
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| Ämnen: | |
| Länkar: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC232425/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9315635/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.17.10.5771 |
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