Coexpression of GM-CSF and antigen in DNA prime-adenoviral vector boost immunization enhances polyfunctional CD8+ T cell responses, whereas expression of GM-CSF antigen fusion protein induces autoimmunity

BACKGROUND: Granulocyte-macrophage colony-stimulating factor (GM-CSF) has shown promising results as a cytokine adjuvant for antiviral vaccines and in various models of tumor gene therapy. To explore whether the targeting of antigens to GM-CSF receptors on antigen-presenting cells enhances antigen-s...

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Bibliographic Details
Main Authors: Tenbusch, Matthias, Kuate, Seraphin, Tippler, Bettina, Gerlach, Nicole, Schimmer, Simone, Dittmer, Ulf, Überla, Klaus
Format: Artigo
Language:Inglês
Published: BioMed Central 2008
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2324072/
https://ncbi.nlm.nih.gov/pubmed/18405363
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2172-9-13
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